Johan Kuiper | BioPharmaceutics

Universiteit Leiden

Johan Kuiper, Prof. Dr.

Position:

Professor of Therapeutic Immunomodulation

Telephone number: +31 (0)71 527 4378
E-mail address: j.kuiper@lacdr.leidenuniv.nl
Faculty/Unit: Faculty of Science, Leiden/Amsterdam Center for Drug Research, BioPharmaceutics
Office address: Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber HB 830

Biography: Dr. Kuiper studied biology, specializing in biochemistry and immunology at the University of Groningen. After graduation in 1984, he obtained his PhD from Leiden University in 1989. In 2007, he became Director of Education of the LACDR, and in November 2008 he became Professor of Therapeutic Immunomodulation at Leiden University. His present research is mainly focused at immunomodulation of inflammatory responses that lead to the development of atherosclerotic plaques. The regulation of pro-inflammatory cytokines by various strategies such as tolerance induction, [DNA] vaccination and modulation of the activity of natural killer T cells is the main topic of research. In addition dendritic cell therapy is exploited as a new therapy for atherosclerosis. Dr. Kuiper was an Established Investigator of the Netherlands Heart Foundation.

2010

van Es, T., van Puijvelde, G.H., Foks, A.C., Habets, K.L., Bot, I, Gilboa, E., Van Berkel, T.J., Kuiper, J. , Vaccination against Foxp3(+) regulatory T cells aggravates atherosclerosis, Atherosclerosis, vol. 209, no. 1, pp. 74-80.

Habets, K.L.L., van Puijvelde, G.H.M., van Duivenvoorde, L.M., van Wanrooij, E.J.A., de Vos, P., Tervaert, J.W.C., van Berkel, T.J.C., Toes, R.E.M., Kuiper, J. , Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice, Cardiovascular Research, vol. 85, no. 3, pp. 622-630.

Hoekstra, M., Li, Z., Kruijt, J.K., Van Eck, M., Van Berkel, T.J., Kuiper, J. , The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status, J Hepatol, vol. 52, no. 2, pp. 244-51.

Hoekstra, M., van der Lans, C.A., Halvorsen, B., Gullestad, L., Kuiper, J., Aukrust, P., van Berkel, T.J., Biessen, E.A. , The peripheral blood mononuclear cell microRNA signature of coronary artery disease, Biochem Biophys Res Commun, vol. 394, no. 3, pp. 792-7.

2009

de Jager, S.C., Cante-Barrett, K., Bot, I, Husberg, C., van Puijvelde, G.H., van Santbrink, P.J., Yndestad, A., van den Oever, J.M., Kuiper, J., van Berkel, T.J., Lipp, M., Zwaginga, J.J., Fibbe, W.E., Aukrust, P., Biessen, E.A. , Impaired effector memory T-cell regulation facilitates graft versus host disease in CCR7-deficient bone marrow transplant chimeras, Transplantation, vol. 88, no. 5, pp. 631-9.

van Es, T., van Puijvelde, G.H., Ramos, O.H., Segers, F.M., Joosten, L.A., van den Berg, W.B., Michon, I.M., de Vos, P., van Berkel, T.J., Kuiper, J. , Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice, Biochem Biophys Res Commun, vol. 388, no. 2, pp. 261-5.

van Puijvelde, G.H., van Wanrooij, E.J., Hauer, A.D., de Vos, P., van Berkel, T.J., Kuiper, J. , Effect of natural killer T cell activation on the initiation of atherosclerosis, Thromb Haemost, vol. 102, no. 2, pp. 223-30.

Hoekstra, M., Ye, D., Hildebrand, R.B., Zhao, Y., Lammers, B., Stitzinger, M., Kuiper, J., Van Berkel, T.J., Van Eck, M. , Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production, J Lipid Res, vol. 50, issue 6, pp. 1039-46.

2008

Hauer, A.D., Habets, K.L., van Wanrooij, E.J., de Vos, P., Krueger, J., Reisfeld, R.A., van Berkel, T.J., Kuiper, J. , Vaccination against TIE2 reduces atherosclerosis, Atherosclerosis.

van Wanrooij, E.J., de Vos, P., Bixel, M.G., Vestweber, D., van Berkel, T.J., Kuiper, J. , Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein receptor-deficient mice, Cardiovasc Res, vol. 78, no. 3, pp. 590-6.

Out, R., Jessup, W., Le Goff, W., Hoekstra, M., Gelissen, I.C., Zhao, Y., Kritharides, L., Chimini, G., Kuiper, J., Chapman, M.J., Huby, T., Van Berkel, T.J., Van Eck, M. , Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1, Circ Res, vol. 102, no. 1, pp. 113-20.

Out, R., Hoekstra, M., Habets, K., Meurs, I, de Waard, V., Hildebrand, R.B., Wang, Y., Chimini, G., Kuiper, J., Van Berkel, T.J., Van Eck, M. , Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels, Arterioscler Thromb Vasc Biol, vol. 28, no. 2, pp. 258-64.

van Wanrooij, E.J., de Jager, S.C., van Es, T., de Vos, P., Birch, H.L., Owen, D.A., Watson, R.J., Biessen, E.A., Chapman, G.A., van Berkel, T.J., Kuiper, J. , CXCR3 antagonist NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor-deficient mice, Arterioscler Thromb Vasc Biol, vol. 28, no. 2, pp. 251-7.

2007

Hauer, A.D., van Puijvelde, G.H., Peterse, N., de Vos, P., van Weel, V., van Wanrooij, E.J., Biessen, E.A., Quax, P.H., Niethammer, A.G., Reisfeld, R.A., van Berkel, T.J., Kuiper, J. , Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis, Arterioscler Thromb Vasc Biol, vol. 27, no. 9, pp. 2050-7.

Kuiper, J., van Puijvelde, G.H., van Wanrooij, E.J., van Es, T., Habets, K., Hauer, A.D., van den Berkel, T.J. , Immunomodulation of the inflammatory response in atherosclerosis, Curr Opin Lipidol, vol. 18, no. 5, pp. 521-6.

Fledderus, J.O., van Thienen, J.V., Boon, R.A., Dekker, R.J., Rohlena, J., Volger, O.L., Bijnens, A.P., Daemen, M.J., Kuiper, J., van Berkel, T.J., Pannekoek, H., Horrevoets, A.J. , Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2, Blood, vol. 109, no. 10, pp. 4249-57.

Out, R., Hoekstra, M., Meurs, I, de Vos, P., Kuiper, J., Van Eck, M., Van Berkel, T.J. , Total body ABCG1 expression protects against early atherosclerotic lesion development in mice, Arterioscler Thromb Vasc Biol, vol. 27, no. 3, pp. 594-9.

Volger, O.L., Fledderus, J.O., Kisters, N., Fontijn, R.D., Moerland, P.D., Kuiper, J., van Berkel, T.J., Bijnens, A.P., Daemen, M.J., Pannekoek, H., Horrevoets, A.J. , Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis, Am J Pathol, vol. 171, no. 1, pp. 326-37.

van Wanrooij, E.J., van Puijvelde, G.H., de Vos, P., Yagita, H., van Berkel, T.J., Kuiper, J. , Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice, Arterioscler Thromb Vasc Biol, vol. 27, no. 1, pp. 204-10.

van Puijvelde, G.H., van Es, T., van Wanrooij, E.J., Habets, K.L., de Vos, P., van der Zee, R., van Eden, W., van Berkel, T.J., Kuiper, J. , Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis, Arterioscler Thromb Vasc Biol, vol. 27, no. 12, pp. 2677-83.

2006

van Puijvelde, G.H., Hauer, A.D., de Vos, P., van den Heuvel, R., van Herwijnen, M.J., van der Zee, R., van Eden, W., van Berkel, T.J., Kuiper, J. , Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis, Circulation, vol. 114, no. 18, pp. 1968-76.

Hoekstra, M., Stitzinger, M., van Wanrooij, E.J., Michon, I.N., Kruijt, J.K., Kamphorst, J., Van Eck, M., Vreugdenhil, E., Van Berkel, T.J., Kuiper, J. , Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet, J Lipid Res, vol. 47, no. 10, pp. 2198-207.

Hauer, A.D., de Vos, P., Peterse, N., ten Cate, H., van Berkel, T.J., Stassen, F.R., Kuiper, J. , Delivery of Chlamydia pneumoniae to the vessel wall aggravates atherosclerosis in LDLr-/- mice, Cardiovasc Res, vol. 69, no. 1, pp. 280-8.

2005

van Berkel, T.J., Out, R., Hoekstra, M., Kuiper, J., Biessen, E., van Eck, M. , Scavenger receptors: friend or foe in atherosclerosis?, Curr Opin Lipidol, vol. 16, no. 5, pp. 525-35.

Meurs, I, Hoekstra, M., van Wanrooij, E.J., Hildebrand, R.B., Kuiper, J., Kuipers, F., Hardeman, M.R., Van Berkel, T.J., Van Eck, M. , HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes, Exp Hematol, vol. 33, no. 11, pp. 1309-19.

Johan currently supervises the following students:

22/01/2010

BioPharmaceutics