Theo van Berkel | BioPharmaceutics

Universiteit Leiden

Theo van Berkel, Prof. Dr.

Theo van Berkel

Position:

Head of Department, Professor of Biopharmaceutics

Telephone number: +31 (0)71 527 6216
E-mail address: t.berkel@lacdr.leidenuniv.nl
Faculty/Unit: Faculty of Science, Leiden/Amsterdam Center for Drug Research, BioPharmaceutics
Office address: Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber HB 824

Biography: In 1971, Professor Van Berkel graduated as a biochemist from the University of Amsterdam. In 1974 he obtained his PhD. from the Erasmus University at Rotterdam. He joined the Center for Bio-Pharmaceutical Sciences in 1986. He was an Established Investigator of the Netherlands Heart Foundation. He is director of the Leiden program of the Netherlands Heart Foundation on "Modulation of gene-expression as therapy for arteriosclerosis". He is a Fellow of the American Heart Association and the Council on Arteriosclerosis, Thrombosis and Vascular Biology and on the Editorial Board of the Journal Arteriosclerosis, Thrombosis and Vascular Biology.

In Press

Eefting, D., Bot, I, de Vries, M.R., Schepers, A., van Bockel, J.H., van Berkel, T.J.C., Biessen, E.A.L., Quax, P.H.A. , Local lentiviral shRNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic APOE*3Leiden mice, Journal of Vascular Surgery.

2010

Ye, D., Meurs, I, Ohigashi, M., Calpe-Berdiel, L., Habets, K.L., Zhao, Y., Kubo, Y., Yamaguchi, A., Van Berkel, T.J., Nishi, T., Van Eck, M. , Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice, Biochem Biophys Res Commun, vol. 395, no. 3, pp. 387-94.

Jennemann, R., Rothermel, U., Wang, S.J., Sandhoff, R., Kaden, S., Out, R., van Berkel, T.J., Aerts, J.M., Ghauharali, K., Sticht, C., Grone, H.J. , Hepatic Glycosphingolipid Deficiency and Liver Function in Mice, Hepatology, vol. 51, no. 5, pp. 1799-1809.

van Es, T., van Puijvelde, G.H., Foks, A.C., Habets, K.L., Bot, I, Gilboa, E., Van Berkel, T.J., Kuiper, J. , Vaccination against Foxp3(+) regulatory T cells aggravates atherosclerosis, Atherosclerosis, vol. 209, no. 1, pp. 74-80.

Bot, M., Bot, I, Lopez-Vales, R., van de Lest, C.H., Saulnier-Blache, J.S., Helms, J.B., David, S., van Berkel, T.J., Biessen, E.A. , Atherosclerotic lesion progression changes lysophosphatidic acid homeostasis to favor its accumulation, Am J Pathol, vol. 176, no. 6, pp. 3073-84.

Zhao, Y., Van Berkel, T.J., Van Eck, M. , Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions, Curr Opin Lipidol.

Hildebrand, R.B., Lammers, B., Meurs, I, Korporaal, S.J., De Haan, W., Zhao, Y., Kruijt, J.K., Pratico, D., Schimmel, A.W., Holleboom, A.G., Hoekstra, M., Kuivenhoven, J.A., Van Berkel, T.J., Rensen, P.C., Van Eck, M. , Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency, Arterioscler Thromb Vasc Biol, vol. 30, no. 7, pp. 1439-45.

de Waard, V., Bot, I, de Jager, S.C., Talib, S., Egashira, K., de Vries, M.R., Quax, P.H., Biessen, E.A., van Berkel, T.J. , Systemic MCP1/CCR2 blockade and leukocyte specific MCP1/CCR2 inhibition affect aortic aneurysm formation differently, Atherosclerosis, vol. 211, no. 1, pp. 84-9.

Bot, I, de Jager, S.C.A., Bot, M., van Heiningen, S.H., de Groot, P., Veldhuizen, R.W., van Berkel, T.J.C., von der Thusen, J.H., Biessen, E.A.L. , The Neuropeptide Substance P Mediates Adventitial Mast Cell Activation and Induces Intraplaque Hemorrhage in Advanced Atherosclerosis, Circulation Research, vol. 106, no. 1, pp. 89-U145.

Habets, K.L.L., van Puijvelde, G.H.M., van Duivenvoorde, L.M., van Wanrooij, E.J.A., de Vos, P., Tervaert, J.W.C., van Berkel, T.J.C., Toes, R.E.M., Kuiper, J. , Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice, Cardiovascular Research, vol. 85, no. 3, pp. 622-630.

Hoekstra, M., Li, Z., Kruijt, J.K., Van Eck, M., Van Berkel, T.J., Kuiper, J. , The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status, J Hepatol, vol. 52, no. 2, pp. 244-51.

Hoekstra, M., van der Lans, C.A., Halvorsen, B., Gullestad, L., Kuiper, J., Aukrust, P., van Berkel, T.J., Biessen, E.A. , The peripheral blood mononuclear cell microRNA signature of coronary artery disease, Biochem Biophys Res Commun, vol. 394, no. 3, pp. 792-7.

Meurs, I, Van Eck, M., Van Berkel, T.J. , High-density lipoprotein: key molecule in cholesterol efflux and the prevention of atherosclerosis, Curr Pharm Des, vol. 16, no. 13, pp. 1445-67.

2009

de Jager, S.C., Cante-Barrett, K., Bot, I, Husberg, C., van Puijvelde, G.H., van Santbrink, P.J., Yndestad, A., van den Oever, J.M., Kuiper, J., van Berkel, T.J., Lipp, M., Zwaginga, J.J., Fibbe, W.E., Aukrust, P., Biessen, E.A. , Impaired effector memory T-cell regulation facilitates graft versus host disease in CCR7-deficient bone marrow transplant chimeras, Transplantation, vol. 88, no. 5, pp. 631-9.

van Es, T., van Puijvelde, G.H., Ramos, O.H., Segers, F.M., Joosten, L.A., van den Berg, W.B., Michon, I.M., de Vos, P., van Berkel, T.J., Kuiper, J. , Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice, Biochem Biophys Res Commun, vol. 388, no. 2, pp. 261-5.

Bot, I, de Jager, S.C., Bot, M., van Heiningen, S.H., van Berkel, T.J., von der Thusen, J.H., Biessen, E.A. , Substance P Mediated Adventitial Mast Cell Activation Induces Intraplaque Hemorrhage in Advanced Atherosclerosis, Circulation, vol. 120, no. 18, pp. S1043-S1043.

Wiersma, H., Nijstad, N., de Boer, J.F., Out, R., Hogewerf, W., Van Berkel, T.J., Kuipers, F., Tietge, U.J. , Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet, Atherosclerosis.

MacDonald, M.L., van Eck, M., Hildebrand, R.B., Wong, B.W., Bissada, N., Ruddle, P., Kontush, A., Hussein, H., Pouladi, M.A., Chapman, M.J., Fievet, C., van Berkel, T.J., Staels, B., McManus, B.M., Hayden, M.R. , Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis, Arterioscler Thromb Vasc Biol, vol. 29, no. 3, pp. 341-7.

Eefting, D., Bot, I, de Vries, M.R., Schepers, A., van Bockel, J.H., Van Berkel, T.J., Biessen, E.A., Quax, P.H. , Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice, J Vasc Surg, vol. 50, no. 1, pp. 152-60.

Hoekstra, M., Lammers, B., Out, R., Li, Z., Van Eck, M., Van Berkel, T.J. , Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice, Mol Pharm, vol. 6, no. 1, pp. 182-9.

Lammers, B., Out, R., Hildebrand, R.B., Quinn, C.M., Williamson, D., Hoekstra, M., Meurs, I, Van Berkel, T.J., Jessup, W., Van Eck, M. , Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development, Atherosclerosis.

Guo, J., Bot, I, de Nooijer, R., Hoffman, S.J., Stroup, G.B., Biessen, E.A., Benson, G.M., Groot, P.H., Van Eck, M., Van Berkel, T.J. , Leucocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in low-density lipoprotein receptor deficient mice, Cardiovasc Res, vol. 81, no. 2, pp. 278-85.

de Nooijer, R., Bot, I, von der Thusen, J.H., Leeuwenburgh, M.A., Overkleeft, H.S., Kraaijeveld, A.O., Dorland, R., van Santbrink, P.J., van Heiningen, S.H., Westra, M.M., Kovanen, P.T., Jukema, J.W., van der Wall, E.E., van Berkel, T.J., Shi, . , Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis, Arterioscler Thromb Vasc Biol, vol. 29, no. 2, pp. 188-94.

van Berkel, T.J. , Bringing retinoid metabolism into the 21st century, J Lipid Res, vol. 50, no. 12, pp. 2337-9.

van Puijvelde, G.H., van Wanrooij, E.J., Hauer, A.D., de Vos, P., van Berkel, T.J., Kuiper, J. , Effect of natural killer T cell activation on the initiation of atherosclerosis, Thromb Haemost, vol. 102, no. 2, pp. 223-30.

09/06/2009

BioPharmaceutics